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This pill really worked for my dog. For us, Apoquel is a bad drug. They were both prescribed Apoquell July over the next few months one dog developed two small growths on his feet that were removed and one found to be malignant the other benign. I am glad that you put this article up because I was hearing the good and the bad people dieing from Creatine, and I havent had any side effects. Subtypes of the anti-metabolites are the anti-folates , fluoropyrimidines, deoxynucleoside analogues and thiopurines. Every dog is different, so you have to try different foods; there is not just ONE right food. It is important not to crush, chew or break metformin ER tablets and swallow the tablet whole.
Recommended Daily Intake
Withhold Tarceva in patients with an overdose or suspected overdose and institute symptomatic treatment. Tarceva erlotinib , a kinase inhibitor, is a quinazolinamine with the chemical name N- 3-ethynylphenyl -6,7-bis 2-methoxyethoxy quinazolinamine.
Tarceva contains erlotinib as the hydrochloride salt that has the following structural formula:. Erlotinib hydrochloride has the molecular formula C 22 H 23 N 3 O 4.
HCl and a molecular weight of The molecule has a pK a of 5. Erlotinib hydrochloride is very slightly soluble in water, slightly soluble in methanol and practically insoluble in acetonitrile, acetone, ethyl acetate and hexane.
Over the pH range of 1. Tarceva tablets for oral administration are available in three dosage strengths containing erlotinib hydrochloride Epidermal growth factor receptor EGFR is expressed on the cell surface of both normal and cancer cells. In some tumor cells signaling through this receptor plays a role in tumor cell survival and proliferation irrespective of EGFR mutation status. Erlotinib reversibly inhibits the kinase activity of EGFR, preventing autophosphorylation of tyrosine residues associated with the receptor and thereby inhibiting further downstream signaling.
Erlotinib binding affinity for EGFR exon 19 deletion or exon 21 LR mutations is higher than its affinity for the wild type receptor. Erlotinib inhibition of other tyrosine kinase receptors has not been fully characterized.
Peak plasma levels occur 4 hours after dosing. Erlotinib is eliminated with a median half-life of Time to reach steady state plasma concentration would therefore be days. The pharmacokinetics of Tarceva in patients with compromised renal function is unknown.
In vitro and in vivo evidence suggest that erlotinib is cleared primarily by the liver. However, erlotinib exposure was similar in patients with moderately impaired hepatic function Child-Pugh B compared with patients with adequate hepatic function including patients with primary liver cancer or hepatic metastases.
In a NSCLC trial, current smokers achieved erlotinib steady-state trough plasma concentrations which were approximately 2-fold less than the former smokers or patients who had never smoked. In another study which was conducted in NSCLC patients who were current smokers, pharmacokinetic analyses at steady-state indicated a dose-proportional increase in erlotinib exposure when the Tarceva dose was increased from mg to mg.
Erlotinib solubility is pH dependent and decreases as pH increases. The studies were negative for carcinogenic findings. The highest dose evaluated in male rats resulted in exposures that were twice those in humans and exposures at the highest tested dose in female rats were slightly lower than those in humans. Erlotinib did not cause genetic damage in a series of in vitro assays bacterial mutation, human lymphocyte chromosome aberration and mammalian cell mutation and in the in vivo mouse bone marrow micronucleus test.
The safety and efficacy of Tarceva as monotherapy for the first-line treatment of patients with metastatic NSCLC containing EGFR exon 19 deletions or exon 21 LR substitution mutations was demonstrated in Study 1, a randomized, open-label, clinical trial conducted in Europe. One hundred seventy-four White patients were randomized 1: The main efficacy outcome measure was progression-free survival PFS as assessed by the investigator.
Baseline demographics of the overall study population were: A protocol-specified analysis of overall survival OS conducted at the time of the final analysis of PFS showed no statistically significant difference between the Tarceva and chemotherapy arms. The HR for OS was 0. Study 2 was a multicenter, placebo-controlled, randomized trial of patients with advanced NSCLC without an EGFR exon 19 deletion or exon 21 LR mutation who had not experienced disease progression after four cycles of platinum-based chemotherapy.
Patients were randomized 1: Following progression on initial therapy, patients were eligible to enter an open-label phase. Baseline characteristics were as follows: The main efficacy outcome was overall survival OS. Median OS was 9. Median PFS was 3. Two randomized, double-blind, placebo-controlled trials, Studies 3 and 4, examined the efficacy and safety of Tarceva administered to patients with metastatic NSCLC as maintenance therapy after initial treatment with chemotherapy Study 3 or with disease progression following initial treatment with chemotherapy Study 4.
Determination of EGFR mutation status was not required for enrollment. The efficacy and safety of Tarceva as maintenance treatment of NSCLC were demonstrated in Study 3, a randomized, double-blind, placebo-controlled trial conducted in 26 countries, in patients with metastatic NSCLC whose disease did not progress during first-line platinum-based chemotherapy. The primary objective of the study was to determine if the administration of Tarceva after standard platinum-based chemotherapy in the treatment of NSCLC resulted in improved progression-free survival PFS when compared with placebo, in all patients or in patients with EGFR immunohistochemistry IHC positive tumors.
Baseline demographics of the overall study population were as follows: Disease characteristics were as follows: The efficacy and safety of single-agent Tarceva was assessed in Study 4, a randomized, double blind, placebo-controlled trial in patients with locally advanced or metastatic NSCLC after failure of at least one chemotherapy regimen.
Patients were randomized 2: Efficacy outcome measures included overall survival, response rate, and progression-free survival PFS. Duration of response was also examined. The primary endpoint was survival. The study was conducted in 17 countries. Tumor characteristics were as follows: The efficacy and safety of Tarceva in combination with gemcitabine as a first-line treatment was assessed in Study 5, a randomized, double-blind, placebo-controlled trial in patients with locally advanced, unresectable or metastatic pancreatic cancer.
Tarceva or placebo was taken orally once daily until disease progression or unacceptable toxicity. Secondary endpoints included response rate, and progression-free survival PFS. The study was conducted in 18 countries. Too few patients were treated in the mg cohort to draw conclusions. In the mg cohort, baseline demographics of the overall study population were as follows: The median time from initial diagnosis to randomization was approximately 1.
Survival was evaluated in the intent-to-treat population. Figure 4 depicts the Kaplan-Meier curves for overall survival in the mg cohort. Kaplan-Meier Curves for Overall Survival: HR is from Cox regression model with the following covariates: ECOG performance status and extent of disease. Advise patients that diarrhea can usually be managed with loperamide and to contact their healthcare provider for severe or persistent diarrhea [see Adverse Reactions 6.
Advise patients of the risk of severe or fatal ILD, including pneumonitis. A review in CNS Drugs determined that "significant psychiatric symptoms including aggression and violence, mania , and less frequently psychosis and suicide have been associated with steroid abuse.
Long-term steroid abusers may develop symptoms of dependence and withdrawal on discontinuation of AAS". Recreational AAS use appears to be associated with a range of potentially prolonged psychiatric effects, including dependence syndromes, mood disorders , and progression to other forms of substance abuse, but the prevalence and severity of these various effects remains poorly understood.
Large-scale long-term studies of psychiatric effects on AAS users are not currently available. DSM-IV lists General diagnostic criteria for a personality disorder guideline that "The pattern must not be better accounted for as a manifestation of another mental disorder, or to the direct physiological effects of a substance e.
As a result, AAS users may get misdiagnosed by a psychiatrist not told about their habit. Affective disorders have long been recognised as a complication of AAS use. From the mids onward, the media reported "roid rage" as a side effect of AAS.
A review determined that some, but not all, randomized controlled studies have found that AAS use correlates with hypomania and increased aggressiveness, but pointed out that attempts to determine whether AAS use triggers violent behavior have failed, primarily because of high rates of non-participation. Compared with individuals that did not use steroids, young adult males that used AAS reported greater involvement in violent behaviors even after controlling for the effects of key demographic variables, previous violent behavior, and polydrug use.
The drug response was highly variable. The mechanism of these variable reactions could not be explained by demographic, psychological, laboratory, or physiological measures. A study of two pairs of identical twins, in which one twin used AAS and the other did not, found that in both cases the steroid-using twin exhibited high levels of aggressiveness, hostility, anxiety, and paranoid ideation not found in the "control" twin.
The relationship between AAS use and depression is inconclusive. There have been anecdotal reports of depression and suicide in teenage steroid users,  but little systematic evidence. A review found that AAS may both relieve and cause depression, and that cessation or diminished use of AAS may also result in depression, but called for additional studies due to disparate data. Androgens such as testosterone , androstenedione and dihydrotestosterone are required for the development of organs in the male reproductive system , including the seminal vesicles , epididymis , vas deferens , penis and prostate.
The pharmacodynamics of AAS are unlike peptide hormones. However, as fat-soluble hormones, AAS are membrane-permeable and influence the nucleus of cells by direct action. The pharmacodynamic action of AAS begin when the exogenous hormone penetrates the membrane of the target cell and binds to an androgen receptor AR located in the cytoplasm of that cell.
From there, the compound hormone-receptor diffuses into the nucleus, where it either alters the expression of genes  or activates processes that send signals to other parts of the cell. The effect of AAS on muscle mass is caused in at least two ways: It has been hypothesized that this reduction in muscle breakdown may occur through AAS inhibiting the action of other steroid hormones called glucocorticoids that promote the breakdown of muscles. As their name suggests, AAS have two different, but overlapping, types of effects: Some examples of the anabolic effects of these hormones are increased protein synthesis from amino acids , increased appetite, increased bone remodeling and growth, and stimulation of bone marrow , which increases the production of red blood cells.
Through a number of mechanisms AAS stimulate the formation of muscle cells and hence cause an increase in the size of skeletal muscles , leading to increased strength. The androgenic effects of AAS are numerous. Depending on the length of use, the side effects of the steroid can be irreversible.
Processes affected include pubertal growth, sebaceous gland oil production, and sexuality especially in fetal development. Some examples of virilizing effects are growth of the clitoris in females and the penis in male children the adult penis size does not change due to steroids [ medical citation needed ] , increased vocal cord size, increased libido , suppression of natural sex hormones , and impaired production of sperm. Men may develop an enlargement of breast tissue, known as gynecomastia, testicular atrophy, and a reduced sperm count.
Compounds with a high ratio of androgenic to an anabolic effects are the drug of choice in androgen-replacement therapy e. This disassociation is less marked in humans, where all AAS have significant androgenic effects. A commonly used protocol for determining the androgenic: The VP weight is an indicator of the androgenic effect, while the LA weight is an indicator of the anabolic effect.
Two or more batches of rats are castrated and given no treatment and respectively some AAS of interest. Animal studies also found that fat mass was reduced, but most studies in humans failed to elucidate significant fat mass decrements. The effects on lean body mass have been shown to be dose-dependent.
Both muscle hypertrophy and the formation of new muscle fibers have been observed. The hydration of lean mass remains unaffected by AAS use, although small increments of blood volume cannot be ruled out. The upper region of the body thorax, neck, shoulders, and upper arm seems to be more susceptible for AAS than other body regions because of predominance of ARs in the upper body.
After drug withdrawal, the effects fade away slowly, but may persist for more than 6—12 weeks after cessation of AAS use. Overall, the exercise where the most significant improvements were observed is the bench press. The measurement of the dissociation between anabolic and androgenic effects among AAS is based largely on a simple although arguably unsophisticated and outdated model involving rat tissue bioassays.
The intracellular metabolism theory explains how and why remarkable dissociation between anabolic and androgenic effects can occur despite the fact that these effects are mediated through the same signaling receptor, and of course why dissociation is invariably incomplete.
An animal study found that two different kinds of androgen response elements could differentially respond to testosterone and DHT upon activation of the AR. Changes in endogenous testosterone levels may also contribute to differences in myotrophic—androgenic ratio between testosterone and synthetic AAS. Testosterone can be metabolized by aromatase into estradiol , and many other AAS can be metabolized into their corresponding estrogenic metabolites as well. The major effect of estrogenicity is gynecomastia woman-like breasts.
AAS are androstane or estrane steroids. As well as others such as 1-dehydrogenation e. The most commonly employed human physiological specimen for detecting AAS usage is urine, although both blood and hair have been investigated for this purpose. The AAS, whether of endogenous or exogenous origin, are subject to extensive hepatic biotransformation by a variety of enzymatic pathways. The primary urinary metabolites may be detectable for up to 30 days after the last use, depending on the specific agent, dose and route of administration.
A number of the drugs have common metabolic pathways, and their excretion profiles may overlap those of the endogenous steroids, making interpretation of testing results a very significant challenge to the analytical chemist.
Methods for detection of the substances or their excretion products in urine specimens usually involve gas chromatography—mass spectrometry or liquid chromatography-mass spectrometry.
The use of gonadal steroids pre-dates their identification and isolation. Medical use of testicle extract began in the late 19th century while its effects on strength were still being studied. In the s, it was already known that the testes contain a more powerful androgen than androstenone , and three groups of scientists, funded by competing pharmaceutical companies in the Netherlands, Germany, and Switzerland, raced to isolate it.
The chemical synthesis of testosterone was achieved in August that year, when Butenandt and G. Wettstein, announced a patent application in a paper "On the Artificial Preparation of the Testicular Hormone Testosterone Androstenoneol. Clinical trials on humans, involving either oral doses of methyltestosterone or injections of testosterone propionate , began as early as Kennedy was administered steroids both before and during his presidency.
The development of muscle-building properties of testosterone was pursued in the s, in the Soviet Union and in Eastern Bloc countries such as East Germany, where steroid programs were used to enhance the performance of Olympic and other amateur weight lifters.
In response to the success of Russian weightlifters, the U. The new steroid was approved for use in the U. It was most commonly administered to burn victims and the elderly. The drug's off-label users were mostly bodybuilders and weight lifters. Although Ziegler prescribed only small doses to athletes, he soon discovered that those having abused Dianabol suffered from enlarged prostates and atrophied testes. Three major ideas governed modifications of testosterone into a multitude of AAS: Androgens were discovered in the s and were characterized as having effects described as androgenic i.
Although anabolic steroid was originally intended to specifically describe testosterone-derived steroids with a marked dissociation of anabolic and androgenic effect, it is applied today indiscriminately to all steroids with AR agonism-based anabolic effects regardless of their androgenic potency, including even non-synthetic steroids like testosterone itself.
The legal status of AAS varies from country to country: Unlawful distribution or possession with intent to distribute AAS as a first offense is punished by up to ten years in prison. Those guilty of buying or selling AAS in Canada can be imprisoned for up to 18 months. In Canada, researchers have concluded that steroid use among student athletes is extremely widespread.
A study conducted in by the Canadian Centre for Drug-Free Sport found that nearly 83, Canadians between the ages of 11 and 18 use steroids. AAS are readily available without a prescription in some countries such as Mexico and Thailand.
The history of the U. The same act also introduced more stringent controls with higher criminal penalties for offenses involving the illegal distribution of AAS and human growth hormone. By the early s, after AAS were scheduled in the U. In the Controlled Substances Act, AAS are defined to be any drug or hormonal substance chemically and pharmacologically related to testosterone other than estrogens , progestins , and corticosteroids that promote muscle growth.
The act was amended by the Anabolic Steroid Control Act of , which added prohormones to the list of controlled substances , with effect from January 20, In the United Kingdom, AAS are classified as class C drugs for their illegal abuse potential, which puts them in the same class as benzodiazepines. Part 1 drugs are subject to full import and export controls with possession being an offence without an appropriate prescription.
There is no restriction on the possession when it is part of a medicinal product. Part 2 drugs require a Home Office licence for importation and export unless the substance is in the form of a medicinal product and is for self-administration by a person.
Many other countries have similar legislation prohibiting AAS in sports including Denmark,  France,  the Netherlands  and Sweden. United States federal law enforcement officials have expressed concern about AAS use by police officers. It's not that we set out to target cops, but when we're in the middle of an active investigation into steroids, there have been quite a few cases that have led back to police officers," says Lawrence Payne, a spokesman for the United States Drug Enforcement Administration.
Following the murder-suicide of Chris Benoit in , the Oversight and Government Reform Committee investigated steroid usage in the wrestling industry. The documents stated that 75 wrestlers—roughly 40 percent—had tested positive for drug use since , most commonly for steroids. AAS are frequently produced in pharmaceutical laboratories, but, in nations where stricter laws are present, they are also produced in small home-made underground laboratories, usually from raw substances imported from abroad.
As with most significant smuggling operations, organized crime is involved. In the late s, the worldwide trade in illicit AAS increased significantly, and authorities announced record captures on three continents. In , Finnish authorities announced a record seizure of A year later, the DEA seized If not then I will surely going use, but starting from a little quantity. What long term effect it gives to any part of the organ or muscles or does it have any effect with aging.
If not then I will surely going to use it. NO Creatine for me. Rather just work it out in the gym naturally with no suppliments. But getting things in a hurry can have consiquences. Eat right, work out and bare patience. Cause then your muscle mass will last longer when you stop working out. Live long and prosper. All l faced was having to drink too much water some thing l was not used too but was happy coz am not a water person.
Right now l have just gottten pure creatine and l want to try it. Creatine made my brother have a fit and he had only been drinking it for a week.. Dont drink it people because if you do you yourself could end up having fits like my brother.
Is there any way that this can be fixed? It helps me recover amazingly fast this is the only reason I take it anymore, just to recover from injury and it does help me get a little stronger. My blood pressure went up from 78 to When I stopped taking it after a long cycle of about 3 months, it took me almost a year to get out of extremely depressive symptoms like being very mentally fuzzy and suicidal. It was also harder than ever to pump my muscles back up and keep them that way, but eventually after a long break they began to pump up on their own again thus it seems like there can be a depenency.
It also makes my muscles look distinctively soft-a look I find undesireable and distinctive to creatine users. In conclusion, this supplement caused allot of problems for me when I used the 5 ml a day the supplement label usually recommends. I modified my cycles to only several days at a time, only when I get an injury, at half dosages I weigh about lbs and eat calories a day and did not notice any relapses, excess water retention, or any lack of the benefits in strength and recovery time compared to when full dosages were taken on longer cycles.
I think creatine is great when used in moderation, but awful when used as recommended by the supplement label. I was wondering the effects of and if there is any concern of me taking my creatine cycle, while still drinking a 6oz cup of coffe in the morning?
Will this be too much or am I cool to take my creatine in the morning, and drink my coffe like 1 hour later? Im only 15 but ive been lifting weights aggressivley for the past three yrs. Im not your average 15 yr old by any means. Ive been hearing so many good things about creatine but some people say you shouldnt take it under the age of My problem is nobody says why i shouldnt.
I know 18 yr olds that i am physically more mature than, so what makes them less likely to experience sideaffects? What are the exact sideaffects? People having fits, etc. And you retards that dont drink enough water daily with your kidney problems — what other supplements are you taking too?? I went from a long distance runner k,5k to a thrower discus, shotput.
Muscles are good, but too much muscle can be a disadvantage in some aspects of sporting. And stick to the Pure versions — cuz its most likely the extra marketing additives causing all these other problems that people are having.
Creatine definately does give good results no question of that but there are definately side affects such as shortness of breath, kidney problems. Please feel free to mail Thanks. Our son of 31 has taken Creatine in the past.
Was admitted to hospital 6 weeks ago with what they thought was appendix, then after a CT scan, showed he had enlarged spleen. Yesterday, he has been told by consultant at hospital he has an enlarged heart and has to have an echocardigram to find out what is causing this.
You get stronger and your recover time is shrunk to an absolute minimum. Creatine is potentially harmful full on your body and here is why. Well since i wrote here two months ago almost nthg had changed. Guys still think that this substance will kill them, or leave some bad results in their system which in turn will affect their bodies. I dont care what this article says, i would never use a supplement as a source of energy or muscle build up.
How weird you you feel being, as described in this article, deflated? Creatine made my dick grow like 8 inches I got huge and ripped….. So anyone who wants to blame creatine for health problems needs to remember there are no scientifically proven negative side effects. Lmao this is hilarious.
I love all of the wannabes who are looking to get bigger fast while simultaneously being completly oblivious to the facts and stories by others who have had first hand experiences with creatine. Bodybuilding takes time and effort, there are no shortcuts nor are there any cutting edge supplements that will increase your muscle size, strength, or endurance without there being any negative side effects. Anything that increases your muscle size, strength, or endurance DOES affect you in one way or another.
It could be as significant as kidney or liver failure or it may be as small as mood swings or a decrease in anything after you stop taking it. For those of you reading, if only looking big is more important than any of the risks that i have mentioned, you are asking for your system to eventually screw itself up in one way or another and deserve it.
Anybody who is willing to risk all of that just to look big and attain strength is asking for all of these consequences. Now you can bulk up and look big within a period of time with all of the risks and side effects included, or you can play it safe and be a legitamate bodybuilder which will of course take a number of years.
But hey, nothing in life comes easy and if you are looking to get bigger faster without damaging your system, then there are no supplements out there for you and you have to face the fact that real bodybuilding takes TIME and the determination to go through with it days a week without seeing any results in the first several months. I have taken creatine for 4 years… I have experimented with cow creatine and goat creatine.
I have to say this new stuff called synthetic anabolic creatine is the best. I inject it directly into my abdominal muscles and they immediately contract and twitch very rapidly. This is quite painful but I believe it has made a significant improvement. I dare someone to challenge the truths I have spoken, and am prepared to kill them. If anyone wants to see pictures, email me at flamedude yahoo. You can also add me on facebook, my name is Jorge Carillo.
I play football and i wrestle. Nothing personal but most of these people who are against creatine must be jelious ore sumthing..
The only bad thing is that when you stop using it you will feel very tired and will need to go back on it. Creatine is great I have early bird weighlifting and being a highschool student I tend to stay up late. But when I take Creatine in the moring I jsut get so pumped up and eager to life, I love the stuff!
But when I take Creatine in the moring I jsut get so pumped up and eager to lift, I love the stuff! Here is My Interesting story with Creatine. Few weeks backs i started to do intensive work out program and i took branded ce.. After two weeks i went for my routine general check up with the doctor. Nextday i got call from hospital saying that my Liver Enzymes got Elevated.
I was terribly upset and was freaking about Hepatitis. Doctor suggested me to go for Hepatitis test. I was so upset and stopped all my work outs and stopped taking creatine too. After two days i was feeling gastro problems. My stomach was so upset and abdominal pain and pain in the lower left side.
Finally i got my test results back with No Hepatitis. I was so happy and the creatine is cause for this my 3 weeks non sleeping terrible days. I analyzed the whole thing here is my reading with the creatine and cause for my problems. I took Branded creatine product as per there dosage suggestion Like working days two scoops 10gm of creatine after workout and non working days daily in the morning. I did not take enough water while taking the creatin. I suggest to take as much water as possible Minimum water intake when ur with creatine: Never take the dosage as suggested by the product.
Always go for less than 5 gm to keep safe. Never go for Loading Phase because all bodies wont react similar way. Drinking lot of water is very much important than anything other wise u end up with loads of problems.
Never go more than 5 gm. Never take creatine months together take break for every three or four weeks of usage As many sites it suggests that visit doctor before take product. But I suggest educating these doctors is very much important by the manufacturers and health department so that they will give more precautions to their clients.
As a whole My Conclusion with creatine if u got good physique I never suggest u to go for creatine. Protein powder and good diet should me more than good and safe. Not required to experiment on this product on ur body. But if ur desperate and want to use inspite of all Side effects I suggest to use minimum Dosage and lot of water in take.
Hope my story useful to u. If u have any questions u can email me to my id ron. Wow this stuff really works!!!! The joint repairs are taking a lot longer than usual.
Mostly a small twist in my leg joint would disappear within a few days now it takes a few weeks to do the same. This thing started only after i started taking creatine. Could this be because of eating that. The simple solution to all of this? What is the purpose of taking a supplement? People are wanting to get bigger muscles faster, without the hard work. Yes I have taken creatine and all it did for me was make my muscles LOOK bigger from all the water retiention. Dont waste your money.
A little determiniation can give you the energy for that extra rep. Thanks All,I have learnt Buy a Qaulity creatine ,drink plenty of water,use 5gm or less a day use it to make gains lifting , then have a break from taking creatine, use it until your happy with your gains and most of all be carefull listen to your body ill keep using it until i notice a problem, I used the stuff years ago 9 maybe for runnning 2.
I am 14 yrs old. I have been taking creatine ocassionaly, body Fortress powder and i was wondering dosage wise how much i should take if i got started. I was also wondering if this would affect my growth at all. Replying to the 14 yr old. This infomation is my experience only and have no qaulifications in this area Do your own Research I Hope this helps.
I also see faster growth in muscle size. Of course I also eat properly, get good sleep and drink lots of water. I never over-dose on the stuff, I typically take less than recommended and cycle off of it after two months. So, 2 on and 2 off cycle. Im in the weight room after school every day and I was taking Whey Protein and it worked okay but the Creatine is amazing I have seen an increase in my lifting ,and I dont have to drag myself in the weight room.
It gives me the energy to lift that extra rep, add that extra weight and run that extra mile. I am glad that you put this article up because I was hearing the good and the bad people dieing from Creatine, and I havent had any side effects. I was reading the other reply and would Creatine affect my growth if taken reguarly with hard workouts? It was shown by many researches that creatine not only harmless but also gives results comparable to anabolic steroids, when taken properly.
Different people react differently to supplements like creatine and so the best way to actually measure the damaging side effects of creatine is to see for yourself if any do occur. You can then weigh up whether you should continue or discontinue the usage of creatine for yourself. Never go over the recommended dosages though because then damaging effects probably will occur. I took creatine and gained 3 stone of mass, was extremely happy with the results until I suffered a massive heart attack.
I mamaged to survive it but was told that i have to be on medication all my life and that I will be unable to get an erection again because of the water retention. I have lost my wife due to this. I have also lost my house because of buying so much creatine.
If you are skinny, so what, just go down the pub, have 6 pints and screw an ugly fat bird. Some things never change, even with creatine! I have been taking it for over 6 months now, i am 17 and have gained just over a stone. I am also taking whey. Given me good results only problem i do sumtimes get cramp. You will see little to no improvement to your body by taking these other supplements. Especially the ones you see behind the locked glass case, they purposely mark up prices to make it look like you are taking something close to steroids that is legal.
I say, just take creatine along with a multivitamin or with protein shakes if you wanna bulk up fast. If you are dehydrated and taking creatine other shitty supplements you can have a seizure and nearly die in the ER like one of my Soldiers. My sister was blinded from the increase in spinal fluid from using creatine. Her workout partner suffered a blown out spine from resuming a workout too soon after injury, again, creatine softened the conncting tissues that held the inside of the spine inside the spine.
Creatine can be very dangerous for some people. This article is dangerous and irresponsible. The only safe creatine is from food sources.
I am actually shocked they were dumb enough to say that for being cardiologists. Your just an idiot if you think it did. Im a skinney person looking to bulk up what other supplements along with creatine should i use to help speed up the process. You guys are fucking idiots. I took creatine for a couple of months and my heart started to hurt alot one week.
It hurt whenever i tried to breathe and I had constant chest pains. The doctor I went to diagnosed creatine as the problem. I took creatine about a year ago and it was fine to begin with, but the longer I took it the more aggressive I became especially if I had a few beers as well. I stopped taking it becuase of this.
This article seems biast towards people taking it in the way it is written, most of the articles on the internet are to increase the size of the market for people to take it, including probably some of the comments made on the article. So i have been taking creatin for about 2months. Before takin creatine i was very skinny.
If you are serious about getting bigger and looking better then i strongly suggest that YOU take this suppliment! I took creatine for approximately 2 months. The only downsides for me were i had to drink almost twice as much water, some of my previous definition was lost due to bloating, and I would get occasional mood swings with anger.
Anyhow I killed a man for staring at my girl. Now I gotta fight for my life everyday. I joined the Aryan brotherhood and they have access to creatine. But there goes my goodtime. Creatine stole my life! Richard Simmons fuck you too for being such a little punk bitch. It was watching your faggot ass that made me wanna bulk up and become musclebound. I never felt that way watching Chuck Norris. Oh yeah btw — the things that hurt: Now none of those things hurt since I stopped doing that wicked shit.
But I gotta tell my asshole is killing me. Damn here comes a guard. Lot of impurities in all that Chinese shit which it all is. There is no such thing. Creatine is not going to mess your heart up or cause aggression. Of course Chinese contaminated products have the residule poison from the chemicals used in seperating it from meat sources on top of contaminated meat sources plus god knows what proably lead cause those fuckers have it in everything else. With that being said, creatine causes increased atp levels which can increase tycardia in cardiac arythmia sensitive individuals.
As for aortic complications as stated above there exist no evidence of such. Creatine is the most tested supplement in supplement history. I guess just ignorant kids or foolish adults. Oral creatine supplementation is widely used in sportsmen and women. Side effects have been postulated, but no thorough investigations have been conducted to support these assertions.
It is important to know whether long-term oral creatine supplementation has any detrimental effects on kidney function in healthy population. Creatinine, urea, and plasma albumin clearances have been determined in oral creatine consumers 10 months to 5 yr and in a control group.
There were no statistical differences between the control group and the creatine consumer group for plasma contents and urine excretion rates for creatinine, urea, and albumin. Clearance of these compounds did not differ between the two groups.
Thus, glomerular filtration rate, tubular reabsorption, and glomerular membrane permeability were normal in both groups. Neither short-term, medium-term, nor long-term oral creatine supplements induce detrimental effects on the kidney of healthy individuals. Taking a creatine supplement when weight training is safe all you are doing is topping up what ever you burn off during a training session.
I have been taking Creatine since the s. No real harm till recently. My balls fell off. Flushed them down the toilet by mistake. Now i want to focus on my stomach, i know thats the toughest area to work on. So my question is would the creatine have any affect on that? A cold dark stare came over my face. I did some creatine and destroyed the place.
I fucked em both up. Then I fucked a chicken and a pig too, lost my mind for more than a minute or two. Started barking like a dog while jumping around. Climbed on top of the barn then fell to the ground.
Got the screamin shits tried to losen the stress. Stumbled and tripped and rolled in the mess. Please forgive me grandpappy you goddamn old mummy. You scarred me and fucked me, because I trusted you. Why dont you actually work for it here you work out for like what an hour o man thats tough just bench some curl some do some crunches maybe 2 or maybe even 3 pullups and oo wait pushups and then talk for the rest of the time and thats your workout and your arms get big why would you be so proud of that and look and Rodney o i forget his last names but his arms are bigger than your arms and legs put together they are huge and guesss what he didnt do roids or possibly criatine so get a fricken life and actually try and when your done doin creatine youll probably get fat and youll have to take creatine for the rest of your life if you dont wanna get fat plus you dont know what the long term effects are and i have a six pack and it looks good and i didnt cheat.
Creatine for the rest of your life? Everything you posted is so ignorant and completely stupid you should be beaten. Mostly for comedic value. You have the simple minds of sheep! You low IQ brainwashed fools need to get that in your heads. If I wanna take drugs that make ME stronger look better etc. And we All humans Have normal creatines stored in our muscles. Healthy adults can supply themselves with more creatine in meats And many vegetables.
Its great for making you stronger and bulking up, but it also makes you slower, ive noticed a great decrease in my punching speed.
I also know for a fact that sprinters use creatine and show no slow down in cardiac recovery they train just as often with no need in extended rests , so this puts the cardiac muscle recovery issue to question.
I just recently made my purchase of creatine. Just took the first glass. No major side effects that will keep me from taking it. S I plan to take far less than stated in the future next time.
Major dobt of People Like me is whether der will b any hormone imbalance……………… looking forward for an answer…. Well I train about 7 days a week, sometimes times a day.
I wanted to take take creatine for tje extra energy boost, nut after reading all of this I decided not to. Rather figure out your diet that has to do with carbohydrates and protein intakes, and naturally with patience and determination, I believe we all could have a great journey. Training is not a destination, but rather a journey.
People who are goal orientated focus on the means of the end result. Once one goal is reached, another starts. The old fashioned way without scientifically modified supplements is the purest way to seek great fitness, and pure results, see how much you are determined, and stick to the natural way. I weigh the same as when I was in High School. Bought a jar of this shit and started eatin fistfulls of it,mixed with everything.
Did some sit ups and push ups and gained 10 lbs. Got a big ol zit on my dick, though………….. They must use it to speed up tha muscle growth. Otherwise they might keep on doing workout for the whole lifetime nang may gain no or very less muscle. Concequently they put the whole blame on gym. Plz use it and then see the positive effects. I am conducting research on the psychological effects of creatine including levels of aggression, attention and memory. A healthy diet that includes 6 small meals a day, eating only lean meat such as chicken, salmon, tuna, beans as well as green vegetables, fruit, etc..
Workout with weights three days a week and do High intensity interval cardio the other three days per week, and you will have the body that you have always desired in no time. I date a RD registered Dietitian and I can guarantee you that with correct eating and regular exercise that you can get the same results as you can with creatine.
Maybe it wont happen quite as fast and in a nation of fast food and inpatients that might be a turn off but correct nutrition is the only way to get in amazing shape with no side effects. I weight lbs and can bench over lb and run full marathons with a solid 8 min mile pace.
Think about the natural way before wasting you money on chemicals. You can get the same nutrients and protein from chickens and fish supplemented with carbs veggies and fruits. I can see the logic in thinking creatine put water in the heart also, however you should never take it for 5 months straight that is far to long of a cycle, I hope your son recovers.
I tried Creatine as part of a weight loss program, thinking it would improve muscular definition. It packed half a stone on me in a week of pure fluid. I was totally deflated when I went to weigh myself after having trained for a solid 2 days and a rest day then 2 days in a week of 4 sessions, to find my weight was up. I laughed when I read about Creatine retaining fluid in the body and quickly stopped taking it.
I have lost over a stone of weight, hopefully fat, now that all the fluid has gone out of my body after taking Creatine. I did notice when I was taking Creatine how I never had to use the loo much even when I was gulping water down at the gym.
I too have been taking creatine, with some muscle gain but nothing too exciting. My bench is up to lbs, which I think is pretty good as I am no 70 years old. There is nothing wrong with creatine!! As long as you take it as directed you will be fine. As for all of the kidney type side effects, that has been proven to be a myth when it comes to creatine itself.
Any kidney issues can be related to other problems during any type of weight lifting. Weight lifting can cause kidney issues by an indirect route. Strenous weight lifting can damage the muscles. In fact, this is basically how the muscles get bigger. They get damaged a little and heal back stronger.
When muscle tissue is damaged a protein called myoglobin is released. Myoglobin breakdown products can crystalize in the kidneys and damage them. I tried creatine for a few weeks and put on about 3kg of muscle, although i lost it all after stopping. My friend said he got really bad bowel control, and was forced to stop taking it…. I go gym 3 times per week and take a ripped protien and get comments about how much bigger i am getting, i think the key is to stay at it, and eat a balanced diet, after a year or so of dedication you will have awesome gains….
For all the 16 year olds, forget steroids or creatine you dont need it just lift weight, take protien, and change your workout program every 3 months. The people on this blog are actuall users of this product and are admitting they have had complications, just something to think about. It will not effect every person who takes this product, but you really have to think is it worth risking your health…. If you want to improve the look of your body or get stronger there is natural proven methods that should be considered before taking an untested product, you are not mice.
Dont be the test. Also my dad is 70 y. HI everybody one of my suggestions are to take the new creatine tablets.